I have a history with Graves Disease, which has mostly been a non-issue (no meds, etc) for the last 10 years or so. Over the last 5 years, I started experiencing symptoms more consistent with hypothyroid, though T4 was usually normal.
Right now I've got high TSH, TSI, & TPO, with a low-normal T4 (but have also been struggling with weight gain, overall metabolism slump, brain fog, etc). I also have some of the symptoms associated with hyper-thyroid (anxiety, trouble sleeping, occasional palpitations, etc), but if I had to pick, I'd say the hypo (or hypo-like) symptoms are more prevalent (am also willing to attribute all, or none, of it to perimenopause).
I started with a new doctor this past summer, but with covid our appointments have all been online and I never get to ask as many follow up questions as I like :-) She said something about having antibodies for both hyper and hypo thyroid conditions, but from what I can tell, the TSH, TSI and TPO all seem like they could indicate Graves or simply a history of Graves.
Is having all three of these high at the same time a *regular* result of having or having had Graves? I honestly don't recall if I was ever tested for TPO before. I'm mostly not sure how they work together, and beyond “TSH stimulates thyroid” I'm not really sure what the presence of TSI and TPO indicate– if anything. Antibodies to something? Thanks for your insights!