I never had any problems after my uptake and scan back in 2011. I was on methimazole for four years and never had any liver problems. I was on quite a high dose (60 mg) early in my diagnosis, but that only lasted a few months. I soon tapered off and started over at 10 mg and eventually settled on alternating 5 and 10 mg. I never had any liver problems, but I did (do) have problems with my kidneys. Doctors don't think the methimazole is to blame, though. They think it's years of NSAID overuse. Also, at one point my nephrologist took me off one of my BP meds and it helped.
You mentioned that you are hoping to go into remission, but you also mentioned that your gland (thyroid, I assume) is large. Did your endocrinologist say anything to you about the odds of your achieving remission? I had an enlarged thyroid when I was diagnosed, and my endo told me that was an indicator that I was unlikely to achieve remission. It wasn't the news I wanted to hear, but I was glad to know from the outset. Methimazole still worked well for me, even without the expectation of remission. I eventually had a thyroidectomy because I developed a large nodule.