Just to clarify - if your wife is on anti-thyroid medication and it's keeping her thyroid hormones at the correct levels, then the disease is well managed or controlled. The word “remission” is used when patients are able to go off their medications. It doesn't happen for everyone, but that's okay - the drugs are still a good option even if remission isn't your goal.
I'll tell you about some of my experiences, and maybe your wife can relate to some of them. When I was first diagnosed, I was definitely irritable, but that wasn't my number one symptom. I was having tremors. I had a lump on my neck and one of my eyes was more open than the other. Sometimes my feet would get really hot - like burning up, and occasionally I'd have heart palpitations. I also lost a whole bunch of weight to the point that I looked sick. Fortunately, my endocrinologist prescribed methimazole for me and it started working pretty fast. It took care of my symptoms even before my thyroid hormones became normal again. All the irritability went away.
Then I had a bit of a setback. I was on a really high dose, and it seemed like overnight I switched gears and became hypothyroid. I had to go off of my medication for a while. As it cleared out of my system, I gradually became hyperthyroid again, and all my symptoms came back just as before - including the irritability. But then my endo put me on a smaller dose of medication, and everything got better again. (Note: this sort of setback isn't normal, so don't worry about it happening to your wife).
So, how this relates to you and your wife… Don't worry! It's good that your wife is doing well on her medication. She should keep getting blood tests and seeing her endocrinologist on a regular basis to make sure that everything stays on track. If at some point your wife starts to feel her hyperthyroid symptoms (irritability as well as others) return, she should call her endo's office and request an order for a blood test.
She may eventually need to stop taking PTU, but she can choose RAI or thyroidectomy. Then she will need to take thyroid replacement for the rest of her life, and she won't have to worry about hyperthyroid symptoms unless she's on too high of a dose of thyroid replacement hormone. She will still need regular blood tests for the rest of her life, but probably not quite as often as with the anti-thyroid drugs.
Edited emmtee (Nov. 18, 2017 23:26:12)